Tysabri^®

What is Tysabri^®?

Tysabri^® (natalizumab) is a monoclonal antibody approved for the treatment of relapsing forms of multiple sclerosis (RMS) in adults. It belongs to a class of therapies known as selective adhesion molecule inhibitors and is designed to block immune cells from crossing into the brain and spinal cord, where they can cause inflammation and damage.


Tysabri® offers a highly effective treatment option for patients with MS, helping to significantly reduce relapse rates, slow disease progression, and limit the development of new brain lesions.

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How does Tysabri^® work?

In multiple sclerosis (MS), the immune system mistakenly attacks the myelin sheath — the protective covering around nerves that supports proper communication within the brain and body.


One way harmful immune cells reach the central nervous system is by crossing the blood-brain barrier — a protective layer that normally keeps the brain and spinal cord safe.

Tysabri^® works by blocking certain molecules (specifically, alpha-4 integrins) that immune cells use to pass through the blood-brain barrier. By preventing these immune cells from entering the central nervous system, Tysabri reduces inflammation, protects the myelin sheath, and helps maintain nerve function.

While Tysabri is not a cure for MS, it helps stabilize disease activity, reduce relapses, and protect against further neurological damage.

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How much does Tysabri^® cost?

Tysabri^® cost can vary depending on several factors including insurance status and insurance provider. Our team at Rocky Mountain MS Clinic are committed to lowering costs and improving access for our patients.

We work with virtually all leading commercial insurance providers in the greater Intermountain region, including Aetna, Anthem, Blue Cross Blue Shield, Cigna, DMBA, EMI Health, Humana, PEHP Health & Benefits, Select Health, as Tricare, as well as Medicaid and Medicare.

We’re here to make treatment more affordable and less stressful. Our team takes care of prior authorizations and benefits verification for you, and we’ll personally guide you through copay assistance and foundation support programs to help lower your out-of-pocket costs.

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Why Patients Choose Rocky Mountain Infusion Center to Receive Their Tysabri^® Infusion:

Clinical Excellence and Neurological Expertise

Our infusion center is proud to have a board-certified neurologist on-site, along with a team of BSN-prepared and Multiple Sclerosis-certified Registered Nurses, all committed to delivering the highest standard of care for our patients.

Lower Costs and Financial Assistance

We handle prior-authorization, benefits verification, and guide patients through copay assistance and foundation programs to reduce out-of-pocket costs. Additional financial help may be available if you qualify — just ask, and we’ll help you explore every option.

A Cigna report recently found that with a physician-owned infusion site, like RMMSC’s Infusion Center, patients see much lower out-of-pocket and overall costs than they would at a hospital outpatient infusion center.