^Uplizna®

What is Uplizna^®?

Uplizna® (inebilizumab-cdon) is a monoclonal antibody approved for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adults who are anti-AQP4 antibody positive. Like other anti-CD19 therapies, Uplizna is designed to target and deplete B cells — key immune cells involved in driving inflammation and nerve damage in NMOSD. Uplizna® offers an important treatment option for patients with NMOSD, helping to reduce the risk of attacks and prevent long-term disability, with a convenient twice-yearly dosing schedule after the initial doses.

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How does Uplizna^® work?

 In neuromyelitis optica spectrum disorder (NMOSD), the immune system mistakenly attacks the optic nerves and spinal cord, often leading to severe vision loss, paralysis, and other serious symptoms.
B cells, which express the CD19 marker, play a central role in producing harmful antibodies, including those against aquaporin-4 (AQP4), that trigger these attacks.

When these attacks occur, they can cause lasting damage to the nervous system, severely impacting vision, mobility, and overall function.

Uplizna® works by targeting the CD19 marker on B cells, helping to eliminate these cells before they can initiate further attacks. While Uplizna is not a cure for NMOSD, it helps calm the immune system, lower the risk of future attacks, and preserve neurological function over time.

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How much does Uplizna^® cost?

Uplizna^® cost can vary depending on several factors including insurance status and insurance provider. Our team at Rocky Mountain MS Clinic are committed to lowering costs and improving access for our patients.

We work with virtually all leading commercial insurance providers in the greater Intermountain region, including Aetna, Anthem, Blue Cross Blue Shield, Cigna, DMBA, EMI Health, Humana, PEHP Health & Benefits, Select Health, as Tricare, as well as Medicaid and Medicare.

We’re here to make treatment more affordable and less stressful. Our team takes care of prior authorizations and benefits verification for you, and we’ll personally guide you through copay assistance and foundation support programs to help lower your out-of-pocket costs.

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Why Patients Choose Rocky Mountain Infusion Center to Receive Their Uplizna^® Infusion:

Clinical Excellence and Neurological Expertise

Our infusion center is proud to have a board-certified neurologist on-site, along with a team of BSN-prepared and Multiple Sclerosis-certified Registered Nurses, all committed to delivering the highest standard of care for our patients.

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Lower Costs and Financial Assistance

We handle prior-authorization, benefits verification, and guide patients through copay assistance and foundation programs to reduce out-of-pocket costs. Additional financial help may be available if you qualify — just ask, and we’ll help you explore every option.

A Cigna report recently found that with a physician-owned infusion site, like RMMSC’s Infusion Center, patients see much lower out-of-pocket and overall costs than they would at a hospital outpatient infusion center.

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Established leader in MS & Neurological care

35+ years in the Intermountain region, serving thousands of individuals with MS and other neurological disorders.