Vyvgart Hytrulo®

What is Vyvgart Hytrulo®?

Vyvgart Hytrulo® has the same medicine in it as Vyvgart. The difference is how you get it. Vyvgart goes into a vein through an IV and takes about an hour. Vyvgart Hytrulo is a shot under the skin that takes 30 to 90 seconds.

It treats two conditions in adults: generalized myasthenia gravis (gMG), and a nerve condition called CIDP. For CIDP, it was the first treatment with a new approach in more than 30 years.

Here is what treatment looks like:

• Your dose: One shot under the skin, taking 30 to 90 seconds

• How often, for myasthenia gravis: Once a week for 4 weeks, then a break before your next round

• How often, for CIDP: Once a week, ongoing

• Total appointment time: For the first visit, you can expect to stay around 1-1.5 hours. After that you should plan to star 45 min – 1 hour.

If you have CIDP, there is a version you can give yourself at home using a prefilled syringe. It takes about 20 to 30 seconds. Not everyone is a good fit for this, so ask your neurologist whether it makes sense for you. If you do switch to home treatment, we still handle your training, monitoring, and follow-up visits.

How does Vyvgart Hytrulo work?

Antibodies are proteins your immune system makes to fight off germs. Sometimes your body makes antibodies that attack your own tissue by mistake. That is what happens in both of the conditions this drug treats.

In myasthenia gravis, those antibodies block the signals between your nerves and your muscles, so your muscles feel weak.

In CIDP, they attack the protective coating around the nerves in your arms and legs. That causes weakness, numbness, and tingling.

Your body normally recycles antibodies using a receptor called FcRn. The problem is that FcRn recycles the harmful ones too.

Here is what it does:

• Vyvgart Hytrulo blocks FcRn. It stops the recycling process.

• Harmful antibodies get cleared out. Your body breaks them down instead of keeping them.

• For myasthenia gravis: Nerve signals reach your muscles again, so strength improves.

• For CIDP: The attack on your nerve coating slows down, which protects your strength and feeling.

• A second ingredient helps it absorb. Hyaluronidase briefly loosens the tissue under your skin so the full dose can soak in quickly.

In a CIDP study called ADHERE, people on this treatment went significantly longer before their symptoms got worse, compared to people who were not on it.

For myasthenia gravis, it works about the same as the IV version.

Your neurologist will check your progress with simple strength and function tests, and will also ask how you are doing with everyday things. Both matter.

Common side effects:

• Soreness, redness, or swelling where you got your shot — this is the most common one in people with CIDP

• Headache

• Bladder infections

• Infections in your nose, throat, or lungs

Serious side effects — get medical help right away:

• Infections. This medicine lowers your antibody levels, so infections may be harder to fight off. If you are sick, your treatment will be put off until you are better.

• Allergic reactions. These can include a rash, swelling of the face, lips, or throat, or trouble breathing.

• Reactions during or right after your shot. Reported symptoms include high blood pressure, chills, shivering, and pain in the chest, belly, or back. These usually happen within an hour.

• Live vaccines. You should not get live vaccines while on this medicine. Talk with your care team about your shots before each new round.